aetiology an enquiry into
the causes or origin of anything
age-standardised rates - because diseases occur
at different rates in different age-groups it is sometimes difficult to
meaningfully compare the rates in two populations that have different age
structures (since these populations could, for instance, have very different
rates simply due to the fact that people in the populations have different
ages). To get round this we calculate age-standardised rates that
takes into account the age structure of a population so that rates can
be compared.
anaemia occurs when a person does not have
enough red blood cells or haemoglobin (the molecule in red blood cells)
to carry sufficient oxygen around the body
ALL acute lymphoblastic leukaemia. There
is more than one type of white blood cell. Leukaemia is classified
by the type of white blood cell is produced in excess. ALL and CML are
different because they involve the over-production of different sorts of
immature white blood cell.
artefact an artificial product, something
that did not exist until produced or introduced by the process of observation
benzene is a naturally occurring substance
produced by volcanoes and forest fires and present in many plants and animals.
It is also a major industrial chemical made from coal and oil. As
a pure chemical, benzene is a clear, colourless liquid. It is used
to make other chemicals, some types of plastic, detergents, and pesticides.
It is also in a component of petrol. Benzene is an aromatic hydrocarbon
molecule
case definition the criteria that an epidemiologist
sets to identify patients that will be considered as "cases" in an epidemiological
study (this is not necessarily the same as what a doctor would consider
as a "case")
case-control study is an epidemiological
study in which people with a disease are compared to a similar group of
people without the disease to see if there are any differences in their
exposure to agents that are thought to be possible causes of the disease
carcinogen is something that causes
cancer, e.g. benzene is known to be a carcinogen
chromosomes are rod-shaped structures
in the nucleus of cells that contain the genes or hereditary information
cluster is a number of things or events
of the same kind occurring or situated close together. Cases
of a disease can aggregate together either in time or place or both.
This last group are called space-time clusters. Diseases can cluster because
of some shared cause or risk factor or because of the natural history of
the disease or can be due to chance
CML chronic myeloid leukaemia. See ALL
above.
cytotoxic drugs are drugs that kill cancer
cells
DNA deoxyribonucleic acid is a molecule which
controls the structure and function of the cells that make up the human
body. It is found in the chromosomes in the nucleus. Most radiation
damage to cells is thought to involve changes to the DNA. These changes
are known as transformations. The effects of cell transformation may take
may years to appear.
Down's syndrome occurs when a person is
born with an extra chromosome (chromosome 21). People with Down's
syndrome have some degree of mental impairment. They are also more
likely to suffer from a number of other illnesses including leukaemia and
heart problems
effective dose an equivalent dose of
radiation weighted for the susceptibility to harm of different tissues
electron an elementary particle with very
low mass and a negative charge
epidemiology is the study of the frequency
and patterns of disease in groups of people
equivalent dose the absorbed
dose of radiation weighted for the harmfulness of different types of radiation
free radical a grouping of atoms with
an unpaired electron which makes it very chemically reactive
germ cells these are the cells in the body
that carry the genetic information necessary for sexual reproduction.
Sperm and ova are germ cells.
hazard anything which may cause danger
high-LET radiation is the radiation characteristic
of heavy charged particles such as protons and alpha
particles where the distance between ionising events is small
ICD the International Classification of Diseases
is a system of agreed codes for classifying illnesses to help in analysing
data and comparing different groups and places
incidence is the number of new cases
of a disease that occur in a specified period of time (e.g. one year)
in utero in the womb, that is to say, before
birth
ionising radiation "radiation" is a very
broad term and includes visible light, ultraviolet rays, radiowaves, x-rays
etc. When people worry about radiation they usually mean ionising
radiation. Ionising radiation is electromagnetic or particulate radiation
that can cause ionisation (the ejection of an electron from an atom).
When materials emit ionising radiation they are said to be radioactive
(cf. radioactivity)
ionisation the process of forming ions
from neutral atoms
LET linear energy transfer - the average amount
of energy lost per unit track length
leukaemia is a form of cancer, it occurs
when the body makes too many immature white blood cells
low-LET radiation is radiation such as
X-rays or gamma rays where the distance between ionising events is large
lymphoma any cancer of the lymphoid tissue
multifactorial this term means that
a disease (or other outcome of interest) may have more than one cause,
so that a combination of causes (or alternative combinations of causes)
are required to produce it
radioactive decay is the process whereby
radioactive substances break down into other substances
radioactivity describes the property
of some materials to emit ionising radiation. Radioactive materials
have atomic nuclei that are unstable and change or decay into different
more stable nuclei, giving out ionising radiation as they do so.
relative risk (RR) compares the incidence
of a disease in a group with a possible risk factor with the incidence
of the disease in a group who do not have this risk factor. If the
relative risk is 1 then there is no difference in how often the disease
occurs in the two groups. If the relative risk is more than 1 then
the disease is more likely to occur in the group with the risk factor than
the group without the risk factor. If the relative risk is less than
1 then the disease is more common in the group without the "risk factor"
than in the group with it. The relative risk tells you how many times
more common the disease is in the group with the risk factor e.g. a relative
risk of 2 means it is twice as likely, a relative risk of 20 means that
it is 20 times as likely and a relative risk of 0.5 means that it is half
as likely
risk the probability or chance that some event
will happen (usually injury, harm or damage)
statistical significance in order to
decide how to interpret the results of a study we can apply statistical
tests to them. These tests estimate how likely we are to see the
observed (or a more extreme) result if we assume there is no real difference
between what we are looking at and what we are comparing it to. If
the test shows that we are unlikely to see the result we got (e.g. that
it would only happen 1 in 20 or 1 in 100 times) then way say that it is
"statistically significant". We need to specify what level of chance we
are considering as unlikely. (Just because something is very unlikely,
i.e. very "statistically significant", it does not necessarily mean
that it is very important!).
toxin a poisonous substance from an animal
or plant.
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